Ii-negative Mice. Activation of T Cells by Superantigen in Class
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Activation-Induced Apoptosis in T cells: Effect of Age and Caloric Restriction
We have previously shown that the proliferative response of T cells to antigenic or mitogenic stimulus decreased with age and that caloric resection (CR) attenuated the age-related decline in proliferation and IL-2 expression. Because activation-induced apoptosis is known to regulate cell proliferation and eliminate the high number of activated cells during an immune response, it was of interes...
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